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KMID : 0877720080120010027
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Journal of Korean Continence Society
2008 Volume.12 No. 1 p.27 ~ p.35
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Analysis of risk factors associated with male lower urinary tract symptoms in the metabolic syndrome
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Lee Ha-Na
Chung Woo-Sik
Shim Bong-Suk
Hong Young-Sun
Park Hye-Sook
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Abstract
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Purpose: The purpose of this study was to evaluate the relationship between lower urinary tract symptoms (LUTS) and the metabolic syndrome in the elderly male.
Material and Methods : The metabolic syndrome group of 348 patients (64.4+/-8.6 years old) and the control group of 150 patients (66.0+/-7.0 years old) were included in the study. The voiding factors, such as International Prostate Symptom Score (IPSS), quality of life score, prostate volume, maximal urine flow rate, residual urine volume, and prostate-specific antigen (PSA) were investigated. Waist circumference, blood pressure, fasting glucose, HDL-cholesterol, triglyceride were measured for the evaluation of the metabolic syndrome.
Results: Waist circumference (beta=0.025, p<0.001), systolic (beta=0.004, p<0.05) and diastolic blood pressure (beta=0.006, p<0.05) were positively correlated with prostate volume. In the logistic regression analysis of voiding factors according to metabolic syndrome factors, the patients who have central obesity (Odds ratio [OR]=2.931), central obesity and hypertension (OR=3.598), central obesity and diabetes (OR=2.508), hypertension and low HDL-cholesterolemia (OR=2.326), central obesity, hypertension and diabetes (OR=3.083), central obesity, hypertension and low HDL cholesterolemia (OR=3.440) represented a significantly increased age-adjusted risk of benign prostatic enlargement (25g or more). OR of symptomatic benign prostatic hyperplasia (BPH) was 3.178 in the patients with cental obesity, and 2.381 in the patients with both central obesity and hypertension.
Conclusion: In male elderly, the metabolic syndrome was closely related with LUTS and its main risk factor was central obesity, represented as waist circumference.
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KEYWORD
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Risk factors, Metabolic syndrome, Lower urinary tract symptoms
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